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Murine thymic stromal lymphopoietin promotes the differentiation of regulatory T cells from thymic CD4 + CD8 − CD25 − naïve cells in a dendritic cell‐independent manner
Author(s) -
Lee JuneYong,
Lim YuMi,
Park MinJung,
Min SoYoun,
Cho MiLa,
Sung YoungChul,
Park SeHo,
Kim HoYoun,
Cho YoungGyu
Publication year - 2008
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100127
Subject(s) - thymic stromal lymphopoietin , il 2 receptor , foxp3 , microbiology and biotechnology , stromal cell , cd8 , biology , cellular differentiation , t cell , immunology , immune system , chemistry , cancer research , gene , biochemistry
Human thymic stromal lymphopoietin (TSLP) activates dendritic cells (DCs), which promote the proliferation and differentiation of CD4 + T cells. However, murine TSLP (mTSLP) can act directly on CD4 + T cells and bring about their differentiation. We studied the role of mTSLP in the generation of CD4 + CD25 + FoxP3 + T cells from thymocytes. mTSLP promoted the differentiation of CD4 + single‐positive thymocytes into CD4 + CD25 + FoxP3 + T cells. Although we cannot exclude an effect of TSLP mediated through DCs due to co‐stimulatory effects, mTSLP appears to act directly on thymocytes. T‐cell receptor and TSLP receptor signaling act synergistically on thymocytes to generate CD4 + CD25 + FoxP3 + T cells. mTSLP may play an important role in maintaining immune tolerance by promoting the conversion of thymocytes into natural regulatory T cells via escape from negative selection.