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The role of type I interferons in TLR responses
Author(s) -
Noppert Susie J,
Fitzgerald Katherine A,
Hertzog Paul J
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100099
Subject(s) - innate immune system , biology , interferon , immunology , pattern recognition receptor , receptor , signalling pathways , cytokine , immune system , genetics
Recent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern‐recognition receptor signalling, specifically Toll‐like receptors and retinoic acid inducible gene‐like helicases, from the perspective of this 50‐year‐old cytokine. The type I interferon gene family encompasses more than 20 subtypes, whose nature and properties have been extensively studied during its relatively long history. In this review we update and integrate available data on the mechanics of activation of the interferon genes and the role of this cytokine family in the innate immune response.