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Regulating B‐cell activation and survival in response to TLR signals
Author(s) -
Gerondakis Steve,
Grumont Raelene J,
Banerjee Ashish
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100097
Subject(s) - tlr4 , receptor , microbiology and biotechnology , toll like receptor , biology , signal transduction , cell , antigen , cell survival , cell growth , b cell , immunology , apoptosis , antibody , innate immune system , genetics
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B‐cell receptor in a specific antigen‐defined manner, or through Toll‐like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor κ B pathway controls and coordinates B‐cell division and survival following TLR4 engagement.