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Fine‐tuning of the innate immune response by microRNAs
Author(s) -
Gantier Michael P,
Sadler Anthony J,
Williams Bryan R G
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100091
Subject(s) - innate immune system , microrna , biology , rna interference , immune system , pattern recognition receptor , innate lymphoid cell , signal transduction , immunology , rna , microbiology and biotechnology , gene , genetics
MicroRNAs (miRNAs) are emerging as potent regulators of many biological processes, including cellular differentiation and disease. Recently, miRNA has been directly involved in innate immunity and transduction signalling by Toll‐like receptors and the ensuing cytokine response. In this review, we present an overview of what is currently known of the involvement of miRNA and RNA interference components in the fine‐tuning of innate immune responses.