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Toll‐like receptors: structural pieces of a curve‐shaped puzzle
Author(s) -
Huyton Trevor,
Rossjohn Jamie,
Wilce Matthew
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100089
Subject(s) - receptor , innate immune system , signal transduction , microbiology and biotechnology , transcription factor , biology , toll like receptor , acquired immune system , immune system , toll , function (biology) , immunology , gene , genetics
The toll‐like receptors are responsible for recognizing invading pathogens and triggering a primary innate immune response by initiating a signalling pathway that ultimately leads to the activation of nuclear factor‐ κ B (NF‐ κ B). NF‐ κ B induces the transcription of many genes that regulate both the inflammatory response and interferons that help control the development of adaptive immunity. In this review, we concentrate on the structure and function of toll‐like receptors and our current understanding of the complexities of ligand binding, receptor dimerization and signal transduction.