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Optimization of TCR transgenic T cells for in vivo tracking of immune responses
Author(s) -
Stock Angus T,
Mueller Scott N,
Kleinert Lauren M,
Heath William R,
Carbone Francis R,
Jones Claerwen M
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100076
Subject(s) - t cell receptor , immune system , biology , endogeny , adoptive cell transfer , genetically modified mouse , transgene , context (archaeology) , immunology , virology , t cell , antigen , microbiology and biotechnology , genetics , gene , paleontology , endocrinology
T‐cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen‐experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus‐specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T‐cell transfer remains a useful means of tracking antiviral immune responses.