Optimization of TCR transgenic T cells for  in vivo  tracking of immune responses | Zendy

Stock Angus T | Zendy; Mueller Scott N | Zendy; Kleinert Lauren M | Zendy; Heath William R | Zendy; Carbone Francis R | Zendy; Jones Claerwen M | Zendy

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Optimization of TCR transgenic T cells for in vivo tracking of immune responses

Author(s) -

Stock Angus T,

Mueller Scott N,

Kleinert Lauren M,

Heath William R,

Carbone Francis R,

Jones Claerwen M

Publication year - 2007

Publication title -

immunology and cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0818-9641

DOI - 10.1038/sj.icb.7100076

Subject(s) - t cell receptor , immune system , biology , endogeny , adoptive cell transfer , genetically modified mouse , transgene , context (archaeology) , immunology , virology , t cell , antigen , microbiology and biotechnology , genetics , gene , paleontology , endocrinology

T‐cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen‐experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus‐specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T‐cell transfer remains a useful means of tracking antiviral immune responses.

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