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Mathematical models of cytotoxic T‐lymphocyte killing
Author(s) -
Regoes Roland R,
Yates Andrew,
Antia Rustom
Publication year - 2007
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/sj.icb.7100053
Subject(s) - cytotoxic t cell , t lymphocyte , immunology , biology , immune system , genetics , in vitro
By killing infected host cells, cytotoxic T lymphocytes (CTL) mediate an important defense mechanism against viruses and other intracellular pathogens. Quantitative aspects of this killing process have been studied for several decades in vitro . More recently, methods have been developed to measure the timescales of CTL killing in vivo . Here, we review the estimates of kinetic rates involved in CTL killing which were obtained in these studies, and elaborate on the differences between them.