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Cdyl: a new transcriptional co‐repressor
Author(s) -
Caron Cécile,
PivotPajot Christophe,
van Grunsven Leo A,
Col Edwige,
Lestrat Cécile,
Rousseaux Sophie,
Khochbin Saadi
Publication year - 2003
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.embor917
Subject(s) - repressor , biology , genetics , gene , transcription factor
Cdyl (chromodomain‐Y‐like) is a chromodomain‐containing protein that is predominantly expressed during mouse spermiogenesis. In its carboxy‐terminal portion, there is a domain with homology to the coenzyme A (CoA) pocket of the enoyl‐CoA hydratase/isomerase, which is shown here to be able to bind CoA and histone deacetylases (HDACs). It also efficiently represses transcription. Moreover, the binding of Hdac1 represses the ability of Cdyl to bind CoA, and a Cdyl–CoA interaction only occurs in the absence of HDACs. These data suggest that Cdyl is primarily a transcriptional co‐repressor. However, the degradation of cellular Hdac1 and Hdac2, as observed here in the elongating spermatids, may provide an HDAC‐free environment in which Cdyl could bind CoA and participate in the global chromatin remodelling that occurs in these cells.