Premium
IQGAP proteins are integral components of cytoskeletal regulation
Author(s) -
Briggs Michael W,
Sacks David B
Publication year - 2003
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.embor867
Subject(s) - iqgap1 , microbiology and biotechnology , cytokinesis , cytoskeleton , scaffold protein , biology , signal transduction , cell division , cell , genetics
IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca 2+ /calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E‐cadherin‐mediated cell–cell adhesion and β‐catenin‐mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.