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The Ark1/Prk1 family of protein kinases
Author(s) -
Smythe Elizabeth,
Ayscough Kathryn R
Publication year - 2003
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.embor776
Subject(s) - endocytic cycle , microbiology and biotechnology , biology , protein kinase domain , phosphorylation , kinase , cytoskeleton , actin cytoskeleton , protein serine threonine kinases , serine , protein kinase a , biochemistry , endocytosis , gene , receptor , cell , mutant
The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evolution of Ark/Prk family members in different organisms may have allowed the conserved role of the kinase domain, which is required for the phosphorylation of both endocytic and cytoskeletal components, to be coupled to other functional domains.