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NF‐κB activation by protein kinase C isoforms and B‐cell function
Author(s) -
Moscat Jorge,
DiazMeco María T,
Rennert Paul
Publication year - 2003
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.embor704
Subject(s) - transcription factor , microbiology and biotechnology , gene isoform , kinase , biology , function (biology) , signal transduction , nfkb1 , protein kinase a , nf κb , immune system , immunology , genetics , gene
B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor‐κB (NF‐κB) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF‐κB activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B‐cell function through NF‐κB.