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Regulation of flowering time by the protein arginine methyltransferase AtPRMT10
Author(s) -
Niu Lifang,
Lu Falong,
Pei Yanxi,
Liu Chunyan,
Cao Xiaofeng
Publication year - 2007
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7401111
Subject(s) - histone methyltransferase , flowering locus c , biology , methyltransferase , histone methylation , arabidopsis , histone , methylation , histone h4 , histone h3 , ezh2 , arginine , histone h2a , arabidopsis thaliana , microbiology and biotechnology , genetics , dna methylation , gene expression , gene , mutant , amino acid
In plants, histone H3 lysine methyltransferases are important in gene silencing and developmental regulation; however, the roles of histone H4 methylation in plant development remain unclear. Recent studies found a type II histone arginine methyltransferase, AtPRTM5, which is involved in promoting growth and flowering. Here, we purified a dimerized plant‐specific histone H4 methyltransferase, plant histone arginine methyltransferase 10 (PHRMT10), from cauliflower. Arabidopsis thaliana protein arginine methyltransferase 10 (AtPRMT10)—the Arabidopsis homologue of PHRMT10—was shown to be a type I PRMT, which preferentially asymmetrically methylated histone H4R3 in vitro . Genetic disruption of AtPRMT10 resulted in late flowering by upregulating FLOWERING LOCUS C ( FLC ) transcript levels. In addition, we show that AtPRMT10 functions genetically separate from AtPRMT5 , but that each acts to fine‐tune expression of FLC . This work adds an extra layer of complexity to flowering‐time regulation and also sheds light on the importance of asymmetric arginine methylation in plant development.