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Get to grips: steering local actin dynamics with IQGAPs
Author(s) -
Brandt Dominique T.,
Grosse Robert
Publication year - 2007
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7401089
Subject(s) - dynamics (music) , actin , biology , computer science , microbiology and biotechnology , physics , acoustics
IQGAPs are actin‐binding proteins that scaffold numerous interaction partners, transmitting extracellular signals that influence mitogenic, morphological and migratory cell behaviour. However, the precise mechanisms by which IQGAP proteins influence actin dynamics and actin filament structures have been elusive. Now that IQGAP1 has emerged as a potential key regulator of actin‐cytoskeletal dynamics by recruiting both the actin related protein (Arp)2/3 complex and/or formin‐dependent actin polymerizing machineries, we propose that IQGAP1 might coordinate the function of mechanistically different actin nucleators for cooperative localized actin filament production in various cellular processes.