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Messenger RNA conformations in the ribosomal E site revealed by X‐ray crystallography
Author(s) -
Jenner Lasse,
Rees Bernard,
Yusupov Marat,
Yusupova Gulnara
Publication year - 2007
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7401044
Subject(s) - philosophy , chemistry
A comparison of messenger RNA in X‐ray crystal structures of 70S ribosomal complexes in the initiation, post‐initiation and elongation states of translation shows distinct conformational differences in the exit (E) codon. Here, we present structural evidence indicating that, after the initiation event, the E codon nucleotides relax and form a classical A‐helical conformation. This conformation is similar to that of the P and A codons, and is favourable for establishing Watson–Crick interactions with the anticodon of E‐site transfer RNA.