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MAPK signalling: ERK5 versus ERK1/2
Author(s) -
Nishimoto Satoko,
Nishida Eisuke
Publication year - 2006
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400755
Subject(s) - mapk/erk pathway , microbiology and biotechnology , kinase , protein kinase a , signal transduction , nuclear localization sequence , cell growth , biology , mitogen activated protein kinase 3 , biochemistry , cytoplasm
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation motif. Both ERK5 and ERK1/2 are activated by growth factors and have an important role in the regulation of cell proliferation and cell differentiation. Moreover, both the ERK5 and the ERK1/2 pathways are sensitive to PD98059 and U0126, which are two well‐known inhibitors of the ERK pathway. Despite these similarities, recent studies have revealed distinctive features of the ERK5 pathway: ERK5 has a key role in cardiovascular development and neural differentiation; ERK5 nuclear translocation is controlled by its own nuclear localizing and nuclear export activities; and the carboxy‐terminal half of ERK5, which follows its kinase catalytic domain, has a unique function.