The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling | Zendy

Berra Edurne | Zendy; Ginouvès Amandine | Zendy; Pouysségur Jacques | Zendy

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The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling

Author(s) -

Berra Edurne,

Ginouvès Amandine,

Pouysségur Jacques

Publication year - 2006

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.1038/sj.embor.7400598

Subject(s) - hydroxylation , hypoxia inducible factors , transcription factor , hypoxia inducible factor 1 , microbiology and biotechnology , hypoxia (environmental) , gene expression , aryl hydrocarbon receptor nuclear translocator , biochemistry , gene , biology , transcription (linguistics) , proline , pas domain , oxygen , hif1a , chemistry , regulation of gene expression , enzyme , amino acid , linguistics , philosophy , organic chemistry , aryl hydrocarbon receptor

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia‐inducible‐factor (HIF), which controls the expression of several genes, ‘senses’ the oxygen concentration indirectly through the hydroxylation of two proline residues that earmarks the HIF‐α subunits for proteasomal degradation. We review the expression, regulation and function of the HIF prolyl hydroxylases or prolyl hydroxylases domain proteins, which are genuine oxygen sensors.

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