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Remodelling epithelial tubes through cell rearrangements: from cells to molecules
Author(s) -
Neumann Marc,
Affolter Markus
Publication year - 2006
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400597
Subject(s) - adherens junction , microbiology and biotechnology , multicellular organism , morphogenesis , cadherin , cell adhesion , biology , epithelium , cell , adhesion , cell adhesion molecule , desmosome , cell junction , chemistry , genetics , organic chemistry , gene
Epithelial cell movements, such as those that occur during cell intercalation, largely contribute to the formation of epithelial structures during the morphogenesis of multicellular organisms. As the architecture of epithelial tissues relies on strong adhesion between cells at adherens junctions (AJs), the intercalation or rearrangements of epithelial cells might be controlled by modulating the adhesion dynamics of the AJs by internal or external forces. In this review, we describe recent progress in understanding cell rearrangements during epithelial tube remodelling and discuss several models that might account for the developmental control of the spatial dynamics of AJs.