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The chromosome cycle: coordinating replication and segregation
Author(s) -
Blow J. Julian,
Tanaka Tomoyuki U.
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400557
Subject(s) - cell cycle , dna replication , biology , gene duplication , cell division , genetics , chromosome segregation , control of chromosome duplication , dna re replication , chromosome , microbiology and biotechnology , dna , computational biology , computer science , cell , gene
During the cell‐division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.