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The phosphoinositide‐3‐OH‐kinase‐related kinases of Arabidopsis thaliana
Author(s) -
Templeton George W.,
Moorhead Greg B.G.
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400479
Subject(s) - arabidopsis , kinase , arabidopsis thaliana , biology , genome , protein serine threonine kinases , yeast , genetics , microbiology and biotechnology , gene , protein kinase a , computational biology , mutant
The phosphoinositide‐3‐OH‐kinase‐related kinases (PIKKs) are atypical protein kinases exclusive to eukaryotes. They mediate the cellular response to a range of stresses, including genome and RNA surveillance and availability of nutrients for growth. Orthologues of five out of the six PIKK family members are present in plant genomes. Recent studies in plant PIKKs have revealed features unique to, and in common with, other PIKKs. This review summarizes the basic knowledge of these proteins in mammals and yeast in comparison with what is known for Arabidopsis and other plants.