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FtsY, the bacterial signal‐recognition particle receptor, interacts functionally and physically with the SecYEG translocon
Author(s) -
Angelini Sandra,
Deitermann Sandra,
Koch HansGeorg
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400385
Subject(s) - signal recognition particle , signal recognition particle receptor , translocon , protein targeting , microbiology and biotechnology , endoplasmic reticulum , biology , ribosome , protein subunit , signal peptidase , membrane protein , signal peptide , biochemistry , gene , membrane , peptide sequence , rna
Co‐translational membrane targeting of proteins by the bacterial signal‐recognition particle (SRP) requires the specific interaction of the SRP–ribosome nascent chain complex with FtsY, the bacterial SRP receptor (SR). FtsY is homologous to the SRα‐subunit of the eukaryotic SR, which is tethered to the endoplasmic‐reticulum membrane by its interaction with the integral SRβ‐subunit. In contrast to SRα, FtsY is partly membrane associated and partly located in the cytosol. However, the mechanisms by which FtsY associates with the membrane are unclear. No gene encoding an SRβ homologue has been found in bacterial genomes, and the presence of an FtsY‐specific membrane receptor has not been shown so far. We now provide evidence for the direct interaction between FtsY and the SecY translocon. This interaction offers an explanation of how the bacterial SRP cycle is regulated in response to available translocation channels.