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The dynamic organization of gene‐regulatory machinery in nuclear microenvironments
Author(s) -
Zaidi Sayyed K.,
Young Daniel W.,
Choi JeYong,
Pratap Jitesh,
Javed Amjad,
Montecino Martin,
Stein Janet L.,
van Wijnen Andre J.,
Lian Jane B.,
Stein Gary S.
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400337
Subject(s) - medical school , library science , gerontology , medicine , medical education , computer science
Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.