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RNA sequence‐ and shape‐dependent recognition by proteins in the ribonucleoprotein particle
Author(s) -
Stefl Richard,
Skrisovska Lenka,
Allain Frédéric H.T.
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400325
Subject(s) - rna , signal recognition particle rna , rna recognition motif , rna binding protein , ribonucleoprotein , biology , rna silencing , rna induced transcriptional silencing , non coding rna , ribonucleoprotein particle , zinc finger , riboswitch , microbiology and biotechnology , rna editing , genetics , gene , transcription factor , rna interference
At all stages of its life (from transcription to translation), an RNA transcript interacts with many different RNA‐binding proteins. The composition of this supramolecular assembly, known as a ribonucleoprotein particle, is diverse and highly dynamic. RNA‐binding proteins control the generation, maturation and lifespan of the RNA transcript and thus regulate and influence the cellular function of the encoded gene. Here, we review our current understanding of protein–RNA recognition mediated by the two most abundant RNA‐binding domains (the RNA‐recognition motif and the double‐stranded RNA‐binding motif) plus the zinc‐finger motif, the most abundant nucleic‐acid‐binding domain. In addition, we discuss how not only the sequence but also the shape of the RNA are recognized by these three classes of RNA‐binding protein.