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Postsynaptic scaffold proteins at non‐synaptic sites
Author(s) -
Kneussel Matthias
Publication year - 2005
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400319
Subject(s) - postsynaptic density , postsynaptic potential , scaffold protein , synaptic plasticity , neurotransmitter receptor , microbiology and biotechnology , synapse , signal transducing adaptor protein , biology , neuroscience , chemistry , receptor , signal transduction , biochemistry
Synapse‐associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non‐synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule‐ or microfilament‐based motor‐protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein–protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.