Premium
Enhanced bone formation in lipodystrophic PPARγ hyp/hyp mice relocates haematopoiesis to the spleen
Author(s) -
Cock TerrieAnne,
Back Jonathan,
Elefteriou Florent,
Karsenty Gérard,
Kastner Philippe,
Chan Susan,
Auwerx Johan
Publication year - 2004
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400254
Subject(s) - haematopoiesis , endocrinology , medicine , bone marrow , adipogenesis , peroxisome proliferator activated receptor , spleen , stem cell , adipose tissue , biology , chemistry , receptor , microbiology and biotechnology
The peroxisome proliferator‐activated receptor gamma (PPARγ) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARγ in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARγ in fat of lipodystrophic PPARγ hyp/hyp mice, strongly enhanced bone mass and consequentially reduced the bone‐marrow cavity. Consistent with this, PPARγ hyp/hyp mice had a significant decrease in bone marrow cellularity and resorted to extramedullary haematopoiesis in the spleen to maintain haematopoiesis. Our data indicate that antagonizing PPARγ activity in fat could be an effective way to combat osteoporosis and suggest that haematopoietic function should be scrutinized in lipodystrophic subjects.