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Fibulins: physiological and disease perspectives
Author(s) -
Argraves W Scott,
Greene Lisa M,
Cooley Marion A,
Gallagher William M
Publication year - 2003
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/sj.embor.7400033
Subject(s) - fibulin , extracellular matrix , basement membrane , disease , biology , pathological , gene , extracellular , microbiology and biotechnology , genetics , medicine , pathology
The fibulins are a family of proteins that are associated with basement membranes and elastic extracellular matrix fibres. This review summarizes findings from studies of animal models of fibulin deficiency, human fibulin gene mutations, human tumours and injury models that have advanced our understanding of the normal and pathological roles of members of this formerly obscure family.