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Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors
Author(s) -
Shen QianHua,
SchulzeLefert Paul
Publication year - 2007
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/sj.emboj.7601854
Subject(s) - receptor , biology , immune system , compartmentalization (fire protection) , microbiology and biotechnology , signal transduction , innate immune system , function (biology) , nuclear receptor , transcription factor , gene , genetics , biochemistry , enzyme
Plants and animals have evolved structurally related innate immune sensors inside cells to detect the presence of microbial molecules. An evolutionary ancient folding machinery becomes engaged for the synthesis of autorepressed receptor forms in both kingdoms. The receptors act as regulatory signal transduction switches and are activated upon direct or indirect perception of non‐self structures. Recent findings indicate that nucleo‐cytoplasmic partitioning and nuclear activity is critical for the function of several plant immune sensors, thereby linking receptor function to transcriptional reprogramming of host cells for pathogen defense. This implies short signalling pathways and reveals parallels with regulatory control mechanisms of animal steroid receptors.