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Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell‐cycle control
Author(s) -
Nagl Norman G,
Wang Xiaomei,
Patsialou Antonia,
Van Scoy Michael,
Moran Elizabeth
Publication year - 2007
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/sj.emboj.7601541
Subject(s) - biology , swi/snf , chromatin remodeling , microbiology and biotechnology , chromatin , cell cycle , genetics , chromatin structure remodeling (rsc) complex , cell cycle protein , cell , dna
The mammalian SWI/SNF chromatin remodeling complex is becoming increasingly recognized for its role in tumor suppression, based on its ability to regulate accessibility of proliferation‐associated genes to transcription factors. However, understanding the biological role of the complex is complicated because the same complex seemingly plays both positive and negative roles in gene expression. Work described here reveals that a choice between two independently encoded, closely related variants of a major subunit of the ARID protein family determines whether the SWI/SNF complex forms further associations with activator versus repressor complexes. The choice distinguishes assemblies with opposite effects on cell‐cycle activity. The specific complexes control access of factors such as E2F1, Tip60, and HDAC1/2/3 to the promoters of various cell‐cycle‐specific genes, with c‐Myc emerging as a particularly critical target.