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Phosphoinositide 3‐kinase controls early and late events in mammalian cell division
Author(s) -
García Zaira,
Kumar Amit,
Marqués Miriam,
Cortés Isabel,
Carrera Ana C
Publication year - 2006
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/sj.emboj.7600967
Subject(s) - biology , phosphoinositide 3 kinase , microbiology and biotechnology , cell division , genetics , signal transduction , cell , pi3k/akt/mtor pathway
Phosphoinositide 3‐kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin‐dependent kinases. Fine‐tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.