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JunD regulates lymphocyte proliferation and T helper cell cytokine expression
Author(s) -
Meixner Arabella,
Karreth Florian,
Kenner Lukas,
Wagner Erwin F
Publication year - 2004
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/sj.emboj.7600133
Subject(s) - biology , cytokine , microbiology and biotechnology , lymphocyte activation , immunology , cell growth , immune system , t cell , genetics
Transgenic mice broadly expressing JunD (Ubi‐ junD m ) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL‐4, CD25 and CD69. Consistently, in the absence of JunD ( junD −/− ) T cells hyperproliferate following mitogen induction. Moreover, transgenic T helper (Th) 2 cells have decreased IL‐4 and IL‐10 expression, whereas junD −/− Th2 cells secrete higher amounts of both Th2 cytokines. Th1‐polarized junD −/− CD4 + T cells display enhanced IFN‐γ cytokine production associated with upregulated T‐bet expression and downregulated expression of suppressor of cytokine signaling‐1. These novel findings demonstrate a regulatory role of JunD in T lymphocyte proliferation and Th cell differentiation.