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The Use of Angiotensin‐converting Enzyme Inhibitors and Diuretics Is Associated With a Reduced Incidence of Impairment on Cognition in Elderly Women
Author(s) -
Yasar S,
Zhou J,
Varadhan R,
Carlson MC
Publication year - 2008
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100483
Subject(s) - dementia , incidence (geometry) , medicine , cognition , verbal learning , cognitive impairment , audiology , psychology , gerontology , disease , psychiatry , physics , optics
The effects of angiotensin‐converting enzyme inhibitors (ACE‐Is) and diuretics (used as antihypertensive agents) on global and domain‐specific cognitive decline were evaluated in 326 non‐demented community‐dwelling participants over the age of 70 years in the Women's Health and Aging Study II. Time‐dependent Cox proportional hazards regression analysis was used for evaluating the association between parameters. The use of ACE‐I for more than 3 years was associated with reduced incidence of impairment on Mini‐Mental State Examination (MMSE), Trail Making Test‐Part A and Part B (TMT, Parts A and B), Hopkins Verbal Learning Test‐Immediate Recall (HVLT‐I), and Hopkins Verbal Learning Test‐Delayed Recall (HVLT‐D). The use of diuretics for more than 3 years was associated with reduced incidence of impairment on MMSE, TMT, Parts A and B, HVLT‐I, and (HVLT‐D). The presence of vascular disease did not make any difference to these effects. Therefore, the use of ACE‐Is or diuretics was associated with reduced incidence of impairment of both global and domain‐specific cognition in elderly women, and may help delay progression to dementia. Clinical Pharmacology & Therapeutics (2008); 84 , 1, 119–126 doi: 10.1038/sj.clpt.6100483