Use of Nanocarriers for Transdermal Vaccine Delivery | Zendy

Lawson L B | Zendy; Freytag L C | Zendy; Clements J D | Zendy

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Use of Nanocarriers for Transdermal Vaccine Delivery

Author(s) -

Lawson L B,

Freytag L C,

Clements J D

Publication year - 2007

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/sj.clpt.6100425

Subject(s) - nanocarriers , transdermal , stratum corneum , nanotechnology , pharmacology , drug delivery , delivery system , medicine , chemistry , materials science , pathology

Transdermal delivery is a safe, noninvasive method of administering vaccines directly onto bare skin, offering several potential advantages over traditional needle delivery. This technology is limited by the relative inefficiency of transport of large‐molecular‐weight vaccine antigens across intact skin. Recent evidence has shown that this barrier can be overcome by properly structured nanosized particles (nanocarriers). The specialized assembly of each type of nanocarrier gives each unique properties and different interactions within the stratum corneum. The use of nanocarriers for vaccine delivery is a platform technology, applicable to delivery of a variety of existing and potential vaccines . Clinical Pharmacology & Therapeutics (2007) 82 , 641–643. doi: 10.1038/sj.clpt.6100425

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