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Dosing in Obesity: A Simple Solution to a Big Problem
Author(s) -
Han P Y,
Duffull S B,
Kirkpatrick C M J,
Green B
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100381
Subject(s) - dosing , clinical pharmacology , obesity , medicine , body weight , lean body mass , metric (unit) , drug , pharmacology , intensive care medicine , operations management , economics
The global epidemic of obesity has led to an increased prevalence of chronic diseases and need for pharmacological intervention. However, little is known about the influence of obesity on the drug exposure profile, resulting in few clear dosing guidelines for the obese. Here we present a semi‐mechanistic model for lean body weight (LBW) that we believe is sufficiently robust to quantify the influence of body composition on drug clearance, and is therefore an ideal metric for adjusting chronic dosing in the obese. Clinical Pharmacology & Therapeutics (2007) 82 , 505–508. doi: 10.1038/sj.clpt.6100381