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Pharmacologic Advances in the Global Control and Treatment of Malaria: Combination Therapy and Resistance
Author(s) -
Nyunt M M,
Plowe C V
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100361
Subject(s) - malaria , drug resistance , medicine , drug , combination therapy , pharmacology , intensive care medicine , pharmacodynamics , pharmacotherapy , pharmacokinetics , plasmodium falciparum , biology , immunology , microbiology and biotechnology
Combination drug therapy for malaria is recommended both to prevent and to overcome drug resistance. Drug combinations developed for use in Asia are being deployed in Africa, where higher rates of malaria affect the therapeutic and public health objectives of malaria chemotherapy as well as drug safety. Rational consideration of drug mechanisms, pharmacokinetics (PK), pharmacodynamics (PD), and malaria epidemiology should result in more effective combination regimens that retain therapeutic and prophylactic efficacy in the face of resistance.