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Targeting Cell Death
Author(s) -
Hausenloy D J,
Scorrano L
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100352
Subject(s) - medicine
Functional consequences of myocardial or cerebral infarction are the result of excessive cell death. It is patent that preventing cell death is the therapeutic goal in any ischemia‐reperfusion setting. Mitochondria amplify apoptotic cascades and have emerged as crucial organelles in ischemia‐reperfusion. Changes in mitochondrial inner membrane permeability and in the morphology of the organelle are regulated, perhaps interconnected processes that are starting to emerge as novel therapeutic targets for reducing cell death induced by ischemia‐reperfusion. Clinical Pharmacology & Therapeutics (2007) 82 , 370–373. doi: 10.1038/sj.clpt.6100352