Premium
“Stemness” Does Not Explain the Repair of Many Tissues by Mesenchymal Stem/Multipotent Stromal Cells (MSCs)
Author(s) -
Prockop D J
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100313
Subject(s) - mesenchymal stem cell , stem cell , progenitor cell , multipotent stem cell , stem cell transplantation for articular cartilage repair , stromal cell , biology , clinical uses of mesenchymal stem cells , microbiology and biotechnology , adult stem cell , cancer research , medicine , endothelial stem cell , in vitro , genetics
There has recently been an explosion of interest in adult stem/progenitor cells that have the potential to repair tissues, with over 3,000 citations to publications (PubMed) and numerous announcements of clinical trials in which the cells are used to treat individuals with a broad range of diseases. At the same time, the data present a paradox—the cells originally attracted attention because of their stem‐cell–like properties, but the cells frequently repair injured tissues without much evidence of either engraftment or differentiation. Clinical Pharmacology & Therapeutics (2007) 82 , 241–243. doi: 10.1038/sj.clpt.6100313