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Human Embryonic Stem Cell Derivation and Nuclear Transfer: Impact on Regenerative Therapeutics and Drug Discovery
Author(s) -
Cervera R P,
Stojkovic M
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100278
Subject(s) - embryonic stem cell , stem cell , drug discovery , regenerative medicine , biology , microbiology and biotechnology , pharmacology , computational biology , neuroscience , medicine , bioinformatics , genetics , gene
This review aims to introduce current and future uses of human embryonic stem cells derived from in vitro ‐fertilized embryos. These and stem cells derived from parthenogenetic and nuclear transfer embryos could be used for cell therapy, as in vitro cell models for drug discovery/screening, and for studying early human development and pathogenesis of human diseases. However, development of therapeutic and screening applications and products from embryonic stem cells is hampered by several barriers. Therefore, gaps in our current understanding of the basic science of stem cells need to be filled before either application can move forward with confidence. Clinical Pharmacology & Therapeutics (2007) 82 , 310–315; doi: 10.1038/sj.clpt.6100278 ; published online 27 June 2007