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Zebrafish: An Emerging Model System for Human Disease and Drug Discovery
Author(s) -
Kari G,
Rodeck U,
Dicker A P
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100223
Subject(s) - zebrafish , danio , drug discovery , computational biology , model organism , biology , model system , drug development , human disease , disease , vertebrate , systems pharmacology , drug , bioinformatics , genetics , pharmacology , gene , medicine , pathology
In vivo studies represent an essential step in drug development and currently rely largely on mice, yet limitations of mammalian models motivated the search for complementary vertebrate model systems. This review focuses on zebrafish, Danio rerio , as a facile model system to study human disease and drug responses. Zebrafish are particularly suited for this purpose because they represent a vertebrate species, their genome is sequenced, and a large number of synchronously developing, transparent embryos can be produced. Zebrafish embryos are permeable to drugs and can easily be manipulated using well‐established genetic and molecular approaches. Here, we summarize recent work on drug discovery and toxicity in zebrafish embryos. In addition, we provide a synopsis of current efforts to establish disease models in zebrafish focusing on neoplasia. The results of these studies highlight the potential of zebrafish as a viable addition to established animal models by offering medium and, potentially, high throughput capabilities. Clinical Pharmacology & Therapeutics (2007) 82 , 70–80. doi: 10.1038/sj.clpt.6100223 ; published online 9 May 2007