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Pharmacokinetics of 11‐nor‐9‐Carboxy‐Δ 9 ‐Tetrahydrocannabinol (CTHC) After Intravenous Administration of CTHC in Healthy Human Subjects
Author(s) -
GlazSandberg A,
Dietz L,
Nguyen H,
Oberwittler H,
Aderjan Rolf,
Mikus Gerd
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100199
Subject(s) - pharmacokinetics , tetrahydrocannabinol , metabolite , delta 9 tetrahydrocannabinol , pharmacology , dronabinol , δ9 tetrahydrocannabinol , chemistry , half life , medicine , cannabinoid , receptor
After cannabis consumption there is only limited knowledge about the pharmacokinetic (PK) and metabolic properties of 11‐nor‐9‐carboxy‐Δ 9 ‐tetrahydrocannabinol (CTHC), which is formed by oxidative breakdown from Δ 9 ‐tetrahydrocannabinol (THC). Despite widely‐varying concentrations observed in smoking studies, attempts have been made to interpret consumption behavior with special regard to a cumulated or decreasing concentration of CTHC in serum. Ten healthy nonsmoking white male individuals received 5 mg CTHC intravenously over 10 min. Highest serum concentrations of CTHC were observed at the end of the infusion (336.8±61.7 μ g/l) followed by a quick decline. CTHC concentration could be quantified up to 96 h after administration, with a terminal elimination half‐life of 17.6±5.5 h. Total clearance was low (91.2±24.0 ml/min), with renal clearance having only a minor contribution (0.136±0.094 ml/min). This first metabolite‐based kinetic approach will allow an advanced understanding of CTHC PKs data obtained in previous studies with THC. Clinical Pharmacology & Therapeutics (2007) 82 , 63–69. doi: 10.1038/sj.clpt.6100199 ; published online 4 April 2007.