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Grapefruit Juice, a Glass Full of Drug Interactions?
Author(s) -
Kirby B J,
Unadkat J D
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100185
Subject(s) - grapefruit juice , transporter , drug , pharmacology , efflux , chemistry , pharmacokinetics , biochemistry , medicine , gene
Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur via inhibition of CYP3A enzymes. As reported by Glaeser et al . 1 in the March 2007 issue of this journal, there is increasing recognition that GFJ may also affect the activity of influx ( e.g ., OATPs) and efflux ( e.g ., P‐glycoprotein) transporters. This commentary focuses on these interactions between GFJ and drug transporters. Clinical Pharmacology & Therapeutics (2007) 81 , 631–633. doi: 10.1038/sj.clpt.6100185