Grapefruit Juice, a Glass Full of Drug Interactions? | Zendy

Kirby B J | Zendy; Unadkat J D | Zendy

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Grapefruit Juice, a Glass Full of Drug Interactions?

Author(s) -

Kirby B J,

Unadkat J D

Publication year - 2007

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/sj.clpt.6100185

Subject(s) - grapefruit juice , transporter , drug , pharmacology , efflux , chemistry , pharmacokinetics , biochemistry , medicine , gene

Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur via inhibition of CYP3A enzymes. As reported by Glaeser et al . 1 in the March 2007 issue of this journal, there is increasing recognition that GFJ may also affect the activity of influx ( e.g ., OATPs) and efflux ( e.g ., P‐glycoprotein) transporters. This commentary focuses on these interactions between GFJ and drug transporters. Clinical Pharmacology & Therapeutics (2007) 81 , 631–633. doi: 10.1038/sj.clpt.6100185

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