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New Targets for Obesity Pharmacotherapy
Author(s) -
Aronne L J,
ThorntonJones Z D
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100163
Subject(s) - anabolism , energy expenditure , catabolism , energy homeostasis , obesity , clinical pharmacology , food intake , medicine , pharmacotherapy , pharmacology , bioinformatics , endocrinology , biology , metabolism
An understanding of the mechanisms that regulate energy homeostasis is essential for understanding novel obesity therapies. The status of energy reserves is communicated to the brain by adiposity and satiety signals. These signals modify either anabolic or catabolic pathways and, consequently, alter food intake in line with signaled energy requirements. New antiobesity therapies are in development that target anabolic or catabolic regulatory networks to reduce food intake and/or increase energy expenditure to promote weight loss. Clinical Pharmacology & Therapeutics (2007) 81 , 748–752. doi: 10.1038/sj.clpt.6100163