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Challenges in the Discovery and Development of New Agents for the Treatment of Obesity
Author(s) -
Staten M A
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100161
Subject(s) - clinical pharmacology , obesity , medicine , drug discovery , weight loss , anti obesity , body weight , intensive care medicine , pharmacology , drug development , drug , bioinformatics , biology
New pharmacologic agents are being sought to help manage the epidemic of obesity and its consequences. Understanding the challenges of the history of obesity drugs is wise before investing in new obesity agents. Expectations of patients, physicians, and drug company executives are not consistent with characteristics of current agents or most potential new ones. Owing to the complex biology underlying body weight regulation, combinations of agents may be necessary to improve weight loss efficacy. Clinical Pharmacology & Therapeutics (2007) 81 , 753–755. doi: 10.1038/sj.clpt.6100161 ; published online 21 March 2007