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Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated with High‐Dose Simvastatin
Author(s) -
Schick B A,
Laaksonen R,
Frohlich J J,
Päivä H,
Lehtimäki T,
Humphries K H,
Côté H C F
Publication year - 2007
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/sj.clpt.6100124
Subject(s) - simvastatin , atorvastatin , mitochondrial dna , skeletal muscle , muscle biopsy , medicine , pharmacology , placebo , mitochondrial myopathy , clinical pharmacology , endocrinology , biology , biopsy , pathology , genetics , gene , alternative medicine
Statins are generally well tolerated, but can cause myopathy 1 and have been associated with mitochondrial abnormalities. 2 , 3 , 4 , 5 , 6 The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published 7 clinical trial of high‐dose simvastatin or atorvastatin versus placebo. Clinical Pharmacology & Therapeutics (2007) 81 , 650–653. doi: 10.1038/sj.clpt.6100124 ; published online 28 February 2007