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Divergence of hypertrophic growth and fetal gene profile: the influence of β‐blockers
Author(s) -
Du XJ
Publication year - 2007
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0707353
Subject(s) - muscle hypertrophy , medicine , endocrinology , downregulation and upregulation , gene , gene expression , biology , genetics
While the expression patterns of cardiac hypertrophy‐related genes have been well documented and widely used as markers for hypertrophy, recent research has revealed uncoupling of hypertrophy‐related gene profiles and hypertrophic growth. The role of β‐adrenergic signalling in the development of hypertrophy is incompletely understood. The finding of an upregulated expression of hypertrophy‐related genes but a suppressed hypertrophy following β‐blockade reveals previously unrecognized sympatho‐adrenergic mechanisms of hypertrophic growth. British Journal of Pharmacology (2007) 152 , 169–171; doi: 10.1038/sj.bjp.0707353