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Sphingosine‐1‐phosphate and sphingosylphosphorylcholine: two of a kind?
Author(s) -
Alewijnse Astrid E,
Michel Martin C
Publication year - 2006
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706602
Subject(s) - sphingolipid , sphingosine , sphingosine 1 phosphate , lipid signaling , signalling , sphingosine kinase , receptor , signalling pathways , transcription factor , signal transduction , chemistry , microbiology and biotechnology , biochemistry , biology , gene
Sphingosine‐1‐phosphate and sphingosylphosphorylcholine are structurally related signalling molecules. Although they share some biological effects, it is debated whether this involves the same receptors. In this issue, Mathieson and Nixon report that these two lipids activate the same transcription factor but do so via distinct signalling pathways. Against this background, we discuss some of the potential pitfalls in studies comparing the effects of the two sphingolipids. British Journal of Pharmacology (2006) 147 , 347–348. doi: 10.1038/sj.bjp.0706602