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In vitro models: research in physiology and pharmacology of the lower urinary tract
Author(s) -
Moreland Robert B.
Publication year - 2006
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706505
Subject(s) - pharmacology , context (archaeology) , in vivo , molecular pharmacology , urinary system , clinical pharmacology , receptor , in vitro , medicine , physiology , biology , endocrinology , biochemistry , microbiology and biotechnology , paleontology
The physiology and pharmacology of the lower urinary tract has advanced based, in part, due to the in vitro assays that have facilitated this exploration. Such assays have led to the development of novel and selective molecules that have been used to characterize different receptor and enzyme systems in the larger context of in vivo pharmacology. These assays can be classified by sites of action of drugs into the following categories: receptors, effector enzymes and enzymes that terminate the responses. In this review, representative assays are presented based on our experience in male erectile dysfunction. British Journal of Pharmacology (2006) 147 , S56–S61. doi: 10.1038/sj.bjp.0706505