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Agonist‐activated ion channels
Author(s) -
Colquhoun David
Publication year - 2006
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706502
Subject(s) - agonist , ion channel , neuroscience , chemistry , partial agonist , receptor , biophysics , pharmacology , biology , biochemistry
This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens. British Journal of Pharmacology (2006) 147 , S17–S26. doi: 10.1038/sj.bjp.0706502