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Fading of 5‐HT 4 receptor‐mediated inotropic responses to 5‐hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium
Author(s) -
Kaumann Alberto J,
Levy Finn Olav
Publication year - 2006
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706501
Subject(s) - agonist , atrium (architecture) , inotrope , phosphodiesterase , receptor , endocrinology , medicine , desensitization (medicine) , chemistry , xanthine , serotonin , pharmacology , biology , enzyme , biochemistry , atrial fibrillation
Inotropic responses to 5‐hydroxytryptamine (5‐HT) in human and porcine atrium can fade, suggesting 5‐HT 4 receptor desensitization. De Maeyer et al ., however, show in this issue that inhibition of phosphodiesterases with isobutyl‐methyl‐xanthine prevents fading of 5‐HT 4 receptor‐mediated responses to 5‐HT and the partial agonist prucalopride in porcine atrium. British Journal of Pharmacology (2006) 147 , 128–130. doi: 10.1038/sj.bjp.0706501