Fading of 5‐HT 4  receptor‐mediated inotropic responses to 5‐hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium | Zendy

Kaumann Alberto J | Zendy; Levy Finn Olav | Zendy

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Fading of 5‐HT 4 receptor‐mediated inotropic responses to 5‐hydroxytryptamine is caused by phosphodiesterase activity in porcine atrium

Author(s) -

Kaumann Alberto J,

Levy Finn Olav

Publication year - 2006

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0706501

Subject(s) - agonist , atrium (architecture) , inotrope , phosphodiesterase , receptor , endocrinology , medicine , desensitization (medicine) , chemistry , xanthine , serotonin , pharmacology , biology , enzyme , biochemistry , atrial fibrillation

Inotropic responses to 5‐hydroxytryptamine (5‐HT) in human and porcine atrium can fade, suggesting 5‐HT 4 receptor desensitization. De Maeyer et al ., however, show in this issue that inhibition of phosphodiesterases with isobutyl‐methyl‐xanthine prevents fading of 5‐HT 4 receptor‐mediated responses to 5‐HT and the partial agonist prucalopride in porcine atrium. British Journal of Pharmacology (2006) 147 , 128–130. doi: 10.1038/sj.bjp.0706501

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