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Pharmacology of intracellular signalling pathways
Author(s) -
Nahorski Stefan R
Publication year - 2006
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706468
Subject(s) - signalling pathways , signalling , intracellular , signal transduction , molecular pharmacology , pharmacology , receptor , neuroscience , biology , microbiology and biotechnology , computational biology , biochemistry
This article provides a brief and somewhat personalized review of the dramatic developments that have occurred over the last 45 years in our understanding of intracellular signalling pathways associated with G‐protein‐coupled receptor activation. Signalling via cyclic AMP, the phosphoinositides and Ca 2+ is emphasized and these systems have already been revealed as new pharmacological targets. The therapeutic benefits of most of such targets are, however, yet to be realized, but it is certain that the discipline of pharmacology needs to widen its boundaries to meet these challenges in the future. British Journal of Pharmacology (2006) 147 , S38–S45. doi: 10.1038/sj.bjp.0706468