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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
Author(s) -
Gaeta Alessandra,
Hider Robert C
Publication year - 2005
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706416
Subject(s) - neurodegeneration , neuroscience , disease , oxidative stress , therapeutic approach , medicine , neuroprotection , alzheimer's disease , bioinformatics , pharmacology , biology
The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration. British Journal of Pharmacology (2005) 146 , 1041–1059. doi: 10.1038/sj.bjp.0706416