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Dopaminergic neurones: much more than dopamine?
Author(s) -
Seutin Vincent
Publication year - 2005
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706328
Subject(s) - neuroscience , dopaminergic , dopamine , neurotensin , midbrain , cholecystokinin , psychology , dopaminergic pathways , schizophrenia (object oriented programming) , biology , neuropeptide , central nervous system , psychiatry , biochemistry , receptor
Midbrain dopaminergic (DA) neurones sustain important physiological functions such as control of motricity, signalling of the error in prediction of rewards and modulation of emotions and cognition. Moreover, their degeneration leads to Parkinson's disease and they may be dysfunctional in other pathological states, such as schizophrenia and drug abuse. A subset of DA neurones has been known for many years to contain releasable peptides such as neurotensin and cholecystokinin. However, recent experimental evidence indicates that the phenotype of DA neurones may be much more diverse, since it is suggested that, under certain conditions, they may also release glutamate, cannabinoids and even serotonin. British Journal of Pharmacology (2005) 146 , 167–169. doi: 10.1038/sj.bjp.0706328